Titlebook: Inflammation and Cancer; Methods and Protocol Brendan J. Jenkins Book 2018 Springer Science+Business Media, LLC 2018 COPD.arthritis.inflamm

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Modelling Intestinal Carcinogenesis Using In Vitro Organoid Culturesons can be studied both singularly and in combination using conditional alleles that can be induced in a temporal manner. The steps in intestinal carcinogenesis are complex and can be challenging to image in live animals at a cellular level. The ability to culture intestinal epithelial tissue in thr

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Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Miceairway wall remodelling, mucus hypersecretion and progressive airflow limitation. Much of the disease burden and health care utilisation in COPD is associated with the management of its comorbidities and infectious (viral and bacterial) exacerbations (AECOPD). Comorbidities, in particular skeletal m

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Tracking Competent Host Defence to Chronic Inflammation: An In Vivo Model of Peritonitiss, and the efficient resolution of inflammation so as to minimise damage to the host. The peritoneal cavity provides an easily accessible and physiologically relevant system where the delicate balance of these processes may be studied. Here, we describe murine models of peritoneal inflammation that

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Infection Model for the Analysis of Bacterial Pathogenesis and Mucosal Immunologyed by thickening of the colon and inflammation. As a natural pathogen of mice, the infection model has proven critical to the development of our understanding of the pathogenesis of enteric disease and the mucosal immune response. In addition to this, some features of disease such as dysbiosis, infl

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