Titlebook: Inflammasome Signaling and Bacterial Infections; Book 2016

Polk

書目名稱Inflammasome Signaling and Bacterial Infections影響因子(影響力)




書目名稱Inflammasome Signaling and Bacterial Infections影響因子(影響力)學(xué)科排名




書目名稱Inflammasome Signaling and Bacterial Infections網(wǎng)絡(luò)公開度




書目名稱Inflammasome Signaling and Bacterial Infections網(wǎng)絡(luò)公開度學(xué)科排名




書目名稱Inflammasome Signaling and Bacterial Infections被引頻次




書目名稱Inflammasome Signaling and Bacterial Infections被引頻次學(xué)科排名




書目名稱Inflammasome Signaling and Bacterial Infections年度引用




書目名稱Inflammasome Signaling and Bacterial Infections年度引用學(xué)科排名




書目名稱Inflammasome Signaling and Bacterial Infections讀者反饋




書目名稱Inflammasome Signaling and Bacterial Infections讀者反饋學(xué)科排名

Bouquet

General Strategies in Inflammasome Biology,onmental agents. Germline-encoded pattern recognition receptors (PRRs) endow the innate immune system with the ability to detect and mount a rapid response against a given threat. Members of several intracellular PRR families, including the nucleotide-binding domain and leucine-rich repeat containin

強化

Structural Mechanisms in NLR Inflammasome Assembly and Signaling,ide-binding domain (NBD)- and leucine-rich repeat (LRR)-containing proteins (NLRs) that can function as pattern recognition receptors (PRRs). In resting cells, NLR proteins exist in an auto-inhibited, monomeric, and ADP-bound state. Perception of microbial or damage-associated signals results in NLR

abduction

, and the Inflammasome: Battle for Intracellular Dominance,riggers the processing and secretion of the pro-inflammatory cytokines IL-1β and IL-18, as well as the induction of a specialized form of inflammatory cell death termed pyroptosis. Here, we review the mechanisms of inflammasome activation triggered by the intracellular pathogen . serovar Typhimurium

貪婪性

Activation and Evasion of Inflammasomes by ,,equent responses. Microbial pathogens are enormously diverse in terms of the niches they occupy, their metabolic properties and requirements, and the cellular pathways that they target. Nevertheless, innate sensing of pathogens triggers a relatively stereotyped set of responses that involve transcri

MELD

,The Orchestra and Its Maestro: ,’, Fine-Tuning of the Inflammasome Platforms,ia invade the epithelium of the colon and the rectum, inducing a severe inflammatory response from which the symptoms of the disease originate. . are human pathogens able to manipulate and subvert the innate immune system surveillance. . dampens inflammasome activation in epithelial cells. In infect

輕信

Inflammasome Activation by , and Its Implications for Persistence and Immunity,s the main risk factor for gastric cancer development. The pro-inflammatory cytokine IL-1β plays a crucial role in the development of gastric tumors, and polymorphisms in the IL-1 gene cluster resulting in increased IL-1β production have been associated with increased risk for gastric cancer. Recent

疏遠(yuǎn)天際

, and the Inflammasome: From Cytosolic Bacteriolysis to Tumor Immunotherapy,-positive intracellular bacterium evolved to live within the harsh environment of the host cytosol. Further, . can activate a robust cell-mediated immune response that is being harnessed as an immunotherapeutic platform. Access to the cytosol is critical for both causing disease and inducing a prote

征兵

Inflammasome Recognition and Regulation of the , Flagellum,opportunistic pathogen grows in macrophages and causes a fulminant pneumonia termed Legionnaires’ disease. . employs a biphasic life cycle, comprising a replicative, non-virulent, and a stationary, virulent form. In the latter phase, the pathogen produces a plethora of so-called effector proteins, w

責(zé)任