Titlebook: Increasing the Therapeutic Ratio of Radiotherapy; Philip J. Tofilon,Kevin Camphausen Book 2017 Springer International Publishing Switzerla

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Remodeling the Irradiated Tumor Microenvironment: The Fifth R of Radiobiology?,istant disease. Transforming growth factor β (TGFβ) is an example of a critical mediator of the irradiated TME. TGFβ inhibition in the context of radiotherapy is predicated on understanding its mechanistic opposition to therapeutic benefit. Therapeutic strategies to biologically augment radiotherapy

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Stereotactic Body Radiation Therapy (SBRT) or Alternative Fractionation Schedules,till are a potential concern; however, recent clinical trials for a variety of tumor sites have shown good outcomes in properly selected patients. This chapter will discuss the potential for SBRT/SABR to improve the therapeutic response. The use of SBRT/SABR regimens to treat lesions within the lung

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Novel Imaging for Treatment Planning or Tumor Response,adionuclides and functional magnetic resonance imaging (MRI). Other potential preclinical techniques are highlighted where relevant, particularly as they apply to promising translational concepts. Emphasis is placed on integration into treatment planning, adaptive treatment modification, and posttre

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Increasing the Therapeutic Efficacy of Radiotherapy Using Nanoparticles,izing damage to normal tissues. This chapter will highlight the past and current developments of nanomedicines used to increase the therapeutic ratio of radiotherapy for in vitro models and in vivo models, the mechanisms of radiation enhancement and interaction of ionizing radiation with nanoparticl

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Radioprotection as a Method to Enhance the Therapeutic Ratio of Radiotherapy,owing field of clinical research are focusing on the development of agents to protect normal tissues from the deleterious effects of irradiation. In this review, we discuss the characteristics of these agents, the research required to translate these agents into clinical trials, and highlight some challenges and successes in these efforts.

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