Titlebook: Immunotoxicology; Proceedings of the I A. Berlin (Health and Safety Directorate),J. Dean, Conference proceedings 1987 ECSC, EEC, EAEC, Brus

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An In Vitro Model for Studying Cellular and Molecular Mechanisms of Thymic Atrophy Induced by Chlorihe polychlorinated biphenyls (Goldstein, 1980; Poland et al., 1979). Studies carried out in inbred murine strains have shown that the induction of cytochrome P.-450 and other xenobiotic metalbolizing enzymes by TCDD is regulated by a genetic locus (designated the . locus) (reviewed in Poland and Knu

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The Gut Associated Lymphoid Tissue as a Model of a Specialized Immune Subsystem generally now that the primary function of such lympho/reticular tissue is to generate immune effector mechanisms which protect the body against the onslaughts of pathogenic bacteria, viruses and toxins. Because the gut is designed to absorb nutriment and has a vast surface area that is in contact

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Immunodepressive Drugs as Prototype Immunotoxicantsseveral problems of both conceptual and practical importance are still outstanding in this young discipline (1,2), as is readly apparent from various chapters in this volume. Since agents that are therapeutically employed with the objective of obtaining a state of modified immune responsiveness can

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The Toxicology of Biological Response Modifiers brought into complete remission by therapeutic means and are free of detectable disease 5 years or longer after diagnosis. Despite these advances substantial obstacles still remain to be overcome before medical treatments can be generally useful in the management of cancer, particularly of the more

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Altered Immune Function and Host Resistance Following Exposure to Common Airborne Pollutantsbe classed as either gases or particles. Only a limited number of these pollutants has been studied for immunotoxic effects. Those chemicals that have been studied are relatively common, such as ozone (O.), nitrogen dioxide (NO.), sulfur dioxide, sulfates (including sulfuric acid), and fly ashes. Ot

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Immunotoxicity of Organotin Compounds. A Cell Biological Approach to Dialkyltin Induced Thymus Atropn to alter immunological responsiveness,either by an immunosuppression or an immunostimulation. The most conspicuous need is for much more information about the underlying molecular mechanisms. Only then will it be possible to explain why in some cases components of the immune system are so extremel

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L. Adorinient parts, it can be divided into submental fistula and maxillofacial fistula. Its etiology is mostly caused by periapical inflammation of teeth (or apical abscess). Periapical tooth inflammation causes continuous inflammatory exudation in local facial connective tissue, leading to increasing local

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The Neoplastic Consequences of Immunodepressionumoral immunity or by both. They are complicated by an increased incidence of infections and of cancer. In this report we shall consider the various types of malignancies that occur in different immunodeficient states.