Titlebook: Immunotherapy in 2020; Visions and Trends f A. Radbruch,H.-D. Volk,W.-D. Doecke Conference proceedings 2007 Springer-Verlag Berlin Heidelbe

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interlude

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Essential

Post-transcriptional Regulators in Inflammation: Exploring New Avenues in Biological Therapeutics,Such is the case of the signal-responsive mechanisms affecting inflammatory mRNAs containing the AU-rich family of elements (AREs), which are recognized by a?specific subset of RBPs. Intense research in this area has yielded important insight on the specific signals and mechanisms affecting the util

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H. D. Volk,B. Sawitzki,F. Kern,C. H?flich,R. Sabat,P. Reinke

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,Nature’s Choice of Genes Controlling Chronic Inflammation,f autoimmune, degenerative, or allergic character. Rheumatoid arthritis (RA) is by definition a?chronic disease with an autoimmune inflammatory attack on diarthrodial cartilaginous joints. The development of new treatment neutralizing cytokines involved in the inflammatory attack has given relief an

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Targeting of Memory, immunosuppression and the introduction of biologicals such as antibodies targeting cytokines have improved clinical outcomes, immunosuppressive therapy has to be continued to be efficient, thus enhancing the risk of adverse events and undesired side effects. Why can immunosuppression ameliorate, ev

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Post-transcriptional Regulators in Inflammation: Exploring New Avenues in Biological Therapeutics,atter “utilization steps” encompass post-transcriptional mechanisms that gradually and variably impose a?series of flexible-rate limiting controls to modify the abundance of an mRNA and the rate of its translation to protein in response to environmental signals. Mechanistically, post-transcriptional

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