Titlebook: Immunotherapy; Aung Naing,Joud Hajjar Book 2021Latest edition The Editor(s) (if applicable) and The Author(s), under exclusive license to

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Abdulrazzak Zarifa,Juan Lopez-Mattei,Nicolas L. Palaskas,Cezar Iliescu,Jean-Bernard Durand,Peter Y. tinued to be the case despite recent advances in the treatment of acute events, which have proven to decrease disability and improve outcomes. Over recent years, there has been significant growth in the field of acute stroke care and stroke systems of care. This includes improvements in the manageme

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Immunotherapy for Melanoma,n, we provide an overview of the results of recent advances in the adjuvant setting for patients with resected stage III and stage IV melanoma, as well as in patients with melanoma brain metastases. Finally, we provide a brief overview of the current research efforts in the field of immuno-oncology for melanoma.

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Immune Checkpoint Inhibitor (ICI)-Related Cardiotoxicity,toxicities related to immunotherapy are reportedly rare, they can be severe and associated with life-threatening conditions such as fulminant myocarditis, hemodynamic instability, and cardiac arrest. We will review the most commonly reported cardiovascular toxicities associated with ICIs and their management.

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Resistance to Immunotherapy: Mechanisms and Means for Overcoming,rucial to understand the pathophysiology of the tumor-immune system interplay and the mechanisms of immune escape in order to circumvent primary and acquired resistance. Here we provide an outline of the most well-defined mechanisms of resistance and shed light on ongoing efforts to reinvigorate immunoreactivity.

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Renal Toxicity, autoimmune disease with a focus on renal cell cancer in setting of chronic kidney disease (CKD). Transplant rejection in setting of CPI use has been further evaluated with single-center and multicenter retrospective studies, and available data will be presented in this chapter.