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Titlebook: Immunosuppressant Analogs in Neuroprotection; Cesario V. Borlongan,Ole Isacson,Paul R. Sanberg Book 2003 Springer Science+Business Media N

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發(fā)表于 2025-3-21 17:48:33 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Immunosuppressant Analogs in Neuroprotection
編輯Cesario V. Borlongan,Ole Isacson,Paul R. Sanberg
視頻videohttp://file.papertrans.cn/463/462289/462289.mp4
概述Includes supplementary material:
圖書封面Titlebook: Immunosuppressant Analogs in Neuroprotection;  Cesario V. Borlongan,Ole Isacson,Paul R. Sanberg Book 2003 Springer Science+Business Media N
描述In recent years there has been a growing recognition that such widely used immunosuppressant drugs as cyclosporin and FK-506 and their analogs-the neuroimmunophilins-possess significant neurotrophic and neuroprotective properties in addition to their beneficial effects for transplant patients. In Immunosuppressant Analogs in Neuroprotection, pioneers in the field and leading neuroscientists and clinicians working with these drugs survey the most recent scientific evidence showing how they evolved from being purely immunosuppressant "drugs" to neuroprotective "agents." These authorities focus on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders. They discuss their efficacy and mechanisms of action in vitro and in vivo; using these models of CNS disease, they report laboratory studies with compelling clinical indications for Alzheimer‘s disease, Huntington‘s disease, stroke, traumatic brain injury, spinal cord injury, ALS, sciatic nerve injury, and drug addiction. They also present novel hypotheses on the me
出版日期Book 2003
關(guān)鍵詞Alzheimer; Nervous System; Parkinson; dopamine; forebrain; neurons; transplantation
版次1
doihttps://doi.org/10.1007/978-1-59259-315-6
isbn_softcover978-1-4684-9742-7
isbn_ebook978-1-59259-315-6
copyrightSpringer Science+Business Media New York 2003
The information of publication is updating

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Effects of Neuroimmunophilin Ligands on Parkinson’s Disease and Cognitionein of 12 kDa, (FKBP12) . Each of these immunophilins has an inherent enzymatic activity, designated protein foldase, peptidyl prolyl-.-isomerase or rotamase activity . This enzyme acts to rotate X-prolyl bonds in protein substrates by 180° from the . to the . conformer. Binding of each immunosuppre
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Cyclosporin A Protects Striatal Neurons from Mitochondrial Dysfunctionon of this protein may be involved in the pathogenesis of HD .. Recently, CAG expansion has been shown to activate caspase-8, a known trigger of apoptotic cell death .. However, the specific mechanism(s) by which the polyglutamine expansion damages and ultimately destroys neurons remains to be estab
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Inhibition of Lipid Peroxidation by Cyclosporin After Spinal Cord Injury in Ratsrotective effect of CsA may be the result of several mechanisms, and among them, lipid peroxidation (LP) inhibition may play an important role .. Recently, we reported on the inhibitory effect of CsA upon LP in a spinal cord (SC) injury model ..
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Antonio Ibarra,Araceli Diaz-Ruizs of CCT are all covered in detail, and in addition relevant information is provided on epidemiology, clinical assessment, and the role of other diagnostic modalities. This book will prove an invaluable tool fo978-88-470-3902-5978-88-470-2522-6
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Book 2003 vivo; using these models of CNS disease, they report laboratory studies with compelling clinical indications for Alzheimer‘s disease, Huntington‘s disease, stroke, traumatic brain injury, spinal cord injury, ALS, sciatic nerve injury, and drug addiction. They also present novel hypotheses on the me
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rm in real applications. For each of the performance measures, we discuss the optimal values that can be achieved by a given model and what should be considered as acceptable. We also show the relationship between the different measures, which can give more insights when interpreting the results of
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ion, population health surveillance, data representation and integration, and clinical trial support. This history provides the reader with an “family tree” of sorts that shows the evolution of artificial intelligence through the past seven decades and its application to medicine and public health.
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