Titlebook: Immunostimulatory DNA Sequences; Eyal Raz Book 2001 Springer-Verlag Berlin Heidelberg 2001 Antigen.DNA.apoptosis.asthma.bacteria.biology.c

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Mucosal adjuvanticity of immunostimulatory DNA sequences,abolic byproducts. This relatively permeable nature places unique constraints and requirements on the immunocytes which protect mucosal surfaces, and makes these sites particularly susceptible to penetration by infectious agents. Despite the relative efficiency of the mucosal immune system in preven

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Immunostimulatory DNA sequences help to eradicate intracellular pathogens,nd processed into surface presented foreign peptides that serve as a stimulus for antigen-specific T cell receptors, thus informing reactive naive T cells about the invading pathogen. CD8. cytotoxic T lymphocytes (CTL) recognize peptide antigens presented by major histocompatibility complex (MHC) cl

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Activation of the innate immune system by CpG oligodeoxynucleotides: immunoprotective activity and n and facilitates the emergence of antigen-specific immunity (reviewed in [29]). Microorganisms have evolved to avoid such recognition by altering expression of their protein and lipid products [29]. Yet DNA is an indispensable and highly conserved component of all bacteria. Indeed, the genomes of o

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Multiple effects of immunostimulatory DNA on T cells and the role of type I interferons,marize our recent evidence on the capacity of CpG DNA and ODNs to influence various facets of T cell function in vivo. To begin, we discuss the capacity of CpG DNA and other products of microorganisms to cause bystander proliferation of T cells.

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gy and on the potential application of immunostimulatory DNA. ISS hold great promise for influencing the immune response and the authors anticipate that the high efficacy and low toxicity observed in animal models will translate into success in a variety of human clinical applications.978-3-642-6321

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