| 書目名稱 | Immunopharmacogenomics | | 編輯 | Yusuke Nakamura | | 視頻video | http://file.papertrans.cn/463/462269/462269.mp4 | | 概述 | Is the first book on immunopharmacogenomics.Uncovers the role of the immune system in the pathogenesis of many disease conditions.Provides detailed descriptions of TCR and BCR repertoire analysis.Expl | | 圖書封面 |  | | 描述 | .This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor | | 出版日期 | Book 2015 | | 關(guān)鍵詞 | Autoimmune disease; BCR; Cancer therapy; Checkpoint inhibitor; Food allergy; HLA; Immunogenomics; Immunothe | | 版次 | 1 | | doi | https://doi.org/10.1007/978-4-431-55726-5 | | isbn_softcover | 978-4-431-56292-4 | | isbn_ebook | 978-4-431-55726-5 | | copyright | Springer Japan 2015 |
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