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Titlebook: Immunopathology of Insulin; Clinical and Experim Konrad Federlin Book 1971 Springer-Verlag Berlin · Heidelberg 1971 animals.hormone.immune

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發(fā)表于 2025-3-21 17:58:52 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Immunopathology of Insulin
副標(biāo)題Clinical and Experim
編輯Konrad Federlin
視頻videohttp://file.papertrans.cn/463/462268/462268.mp4
叢書名稱Monographs on Endocrinology
圖書封面Titlebook: Immunopathology of Insulin; Clinical and Experim Konrad Federlin Book 1971 Springer-Verlag Berlin · Heidelberg 1971 animals.hormone.immune
描述Soon after the discovery of insulin in 1922, it became clear that the use of this hormone in the treatment of diabetics is often accom- panied by allergy. In 1956 it became possible to determine quantita- tively the insulin-binding antibodies which are responsible for the resistance to insulin. The methods developed since then make it possible to measure minute amounts of the pancreatic hormone in blood and extracellular fluids. There have been many attempts to relate insulin allergy and in- sulin resistance to the primary, secondary or tertiary structure of the or B chains, or both, and more recently, to the proinsulin which is A present in all commercial preparations of insulin, i. e. to the species- specific structure of the C peptide. In the great majority of papers dealing either with the immunogenic and antigenic properties of in- sulin or with the relevant antibodies, the discussion has been restricted to the humoral antibodies. The existence of a brief period of delayed local allergy resulting from the cellular immune response has more or less escaped attention. It is specifically this period of delayed allergy that attracted the interest of Dr. FEDERLIN and his colleagues.
出版日期Book 1971
關(guān)鍵詞animals; hormone; immune response; immunity; insulin; pathology; peptides
版次1
doihttps://doi.org/10.1007/978-3-642-80608-7
isbn_softcover978-3-642-80610-0
isbn_ebook978-3-642-80608-7Series ISSN 0077-1015
issn_series 0077-1015
copyrightSpringer-Verlag Berlin · Heidelberg 1971
The information of publication is updating

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發(fā)表于 2025-3-21 23:00:56 | 只看該作者
Konrad Federlinlimatic change and variability are much more com- plex and pervasive than those of the ozone layer, and a much wider range of national and international issues are involved. The discussions in the 1988 session of the General Assembly of the United Nations revealed a surge of interest and growing awa
板凳
發(fā)表于 2025-3-22 03:00:35 | 只看該作者
Konrad Federlinlimatic change and variability are much more com- plex and pervasive than those of the ozone layer, and a much wider range of national and international issues are involved. The discussions in the 1988 session of the General Assembly of the United Nations revealed a surge of interest and growing awa
地板
發(fā)表于 2025-3-22 06:21:53 | 只看該作者
Konrad Federlinlimatic change and variability are much more com- plex and pervasive than those of the ozone layer, and a much wider range of national and international issues are involved. The discussions in the 1988 session of the General Assembly of the United Nations revealed a surge of interest and growing awa
5#
發(fā)表于 2025-3-22 09:09:02 | 只看該作者
Konrad Federlinted with climatic change and variability are much more com- plex and pervasive than those of the ozone layer, and a much wider range of national and international issues are involved. The discussions in the 1988 session of the General Assembly of the United Nations revealed a surge of interest and growing awa978-3-540-51269-1978-3-642-45670-1
6#
發(fā)表于 2025-3-22 13:56:16 | 只看該作者
Konrad Federlinted with climatic change and variability are much more com- plex and pervasive than those of the ozone layer, and a much wider range of national and international issues are involved. The discussions in the 1988 session of the General Assembly of the United Nations revealed a surge of interest and growing awa978-3-540-51269-1978-3-642-45670-1
7#
發(fā)表于 2025-3-22 20:20:25 | 只看該作者
ted with climatic change and variability are much more com- plex and pervasive than those of the ozone layer, and a much wider range of national and international issues are involved. The discussions in the 1988 session of the General Assembly of the United Nations revealed a surge of interest and growing awa978-3-540-51269-1978-3-642-45670-1
8#
發(fā)表于 2025-3-22 22:12:16 | 只看該作者
Introduction,nly clinical experience in a large out-patient department for diabetics at the First University Medical Clinic, Frankfurt am Main, and, in part, also the out-patient service for diabetics at the Center for Internal Medicine, University of Ulm. Thorough questioning of diabetic patients who had recent
9#
發(fā)表于 2025-3-23 04:36:42 | 只看該作者
Book 1971on has been restricted to the humoral antibodies. The existence of a brief period of delayed local allergy resulting from the cellular immune response has more or less escaped attention. It is specifically this period of delayed allergy that attracted the interest of Dr. FEDERLIN and his colleagues.
10#
發(fā)表于 2025-3-23 06:17:16 | 只看該作者
Brief Review of the Immunology of Insulin,n is a very small molecule in comparison with other proteins. Indeed, . (1937) was able to demonstrate that guinea-pig uterus, immunized with bovine or porcine insulin, reacted by contracting in the presence of the antigen (. technique). . (1950), however, still considered the antigenic property of insulin quite improbable.
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