Titlebook: Immunology of Rheumatic Diseases; Sudhir Gupta,Norman Talal Book 1985 Plenum Publishing Corporation 1985 autoimmunity.diseases.molecular b

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Rheumatoid Factoris (RA), in whom they are present in large amounts and persistently over time, they were designated as rheumatoid factors. They occur, however, in a wide variety of illnesses and can be provoked in almost all normal individuals by appropriate stimuli. In this chapter, we review what is known about t

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Antibodies to DNA Epiphenomena or Pathogens? L.E. cell phenomenon resulted from ingestion of altered nuclear material by circulating phagocytic cells. Close examination of that material showed that it consisted of DNA-protein (predominantly DNA-histone) and IgG. Thus, the existence of antibodies to the supposedly “forbidden” constituents of t

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Neuron-Reactive Antibodies in Systemic Lupus Erythematosus course of the illness. As is true of the effects of SLE elsewhere, there are protean manifestations of central nervous system (CNS) dysfunction, but most commonly it presents as seizures or organic brain syndrome with psychosis and/or impaired mentation. Despite advances in understanding some of th

Mechanics

Antiphospholipid Antibodies are two well-described groups of antiphospholipid antibodies, anticardiolipin antibodies (Pangborn, 1941; De Bruijn, 1966; Inoue and Nojima, 1969; Harris .., 1983, 1985c) and the lupus anticoagulant (Conley and Hartmann, 1952; Margolius .., 1961; Feinstein and Rapaport, 1972; Veltkamp .1974; Byron,

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Immune Response to Collageniself reactivity specific for the cartilage type (native type II) of collagen is an effector mechanism in the connective tissue diseases, rheumatoid arthritis, and relapsing polychondritis. The intent is to update earlier reviews of immunity to collagen (Furthmayr and Timpl, 1976; Beard .., 1977; Tr

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Immune Response to Streptococcal Antigens in Rheumatic Fevere know that rheumatoid arthritis is commonly associated with the production of rheumatoid factors and a positive latex fixation test and that systemic lupus erythematosus represents a generalized often severe disease of connective tissues associated with anti-DNA antibodies, but in neither of the tw

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