Titlebook: Immunology of Aging; Ahmad Massoud,Nima Rezaei Book 2014 Springer-Verlag Berlin Heidelberg 2014 Age-associated diseases.Age-related altera

Prologue

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T Cell-Mediated Immunity in the Immunosenescence Process,ise in the number and proportion of older persons worldwide, one of the challenges of a “l(fā)ong-life society” is to ensure that the years gained are not only healthy and disability-free years but also offering a good quality of life. In this perspective, recent research has concentrated on identifying

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Biological and Phenotypic Alterations of T Cells in Aging,oimmunity in elders. Ageing reduces the number and T cell potential of hematopoietic precursors, and involution of the thymus renders it less capable of supporting de novo T cell development. Consequently, ageing compromises the functions of lymphocytes, resulting in a T cell pool with restricted re

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Contort

Age-Related Alterations in Regulatory T Cells,geing affects different immune cell types, including hematopoietic stem cells, lymphoid progenitors in the bone marrow and thymus, thymic stromal cells, mature lymphocytes in secondary lymphoid organs, and elements of the innate immune system. Importantly, significant alterations are seen in the T l

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ensemble

The Role of MicroRNAs in Immunosenescence Process,. It has recently been recognized that proteins and genes involving in ageing process are precisely regulated by various MicroRNAs. MicroRNAs have been understood as pathway regulators in biological processes such as immune system component development and activation. MicroRNAs have crucial regulato

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Immunogenetics of Aging,the humoral immune response decline with age. The individuals, genetically enriched for longevity, possess different immune signatures comparing to the general population. Human leukocyte antigen and cytokine gene polymorphisms are two examples with some associations with ageing. The genetic factors

Frequency-Range

Optimizing Response to Vaccination in the Elderly,cination) a public health issue. However, normal vaccines that are effective in young and adult individuals are less immunogenic and less protective in the elderly, due to their impaired immune responsiveness. It is therefore necessary to design new vaccines especially suited to raise protective imm

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