Titlebook: Immunological Tolerance; Methods and Protocol Paul J. Fairchild Book 2007 Humana Press 2007 AIDS.Antigen.Immunologie.Thymus.Transplantation

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Isolation, Expansion, and Characterization of Human Natural and Adaptive Regulatory T Cellsl types of T cells with regulatory activity have been described both in mice and humans, and those within the CD4. subset have been extensively studied. Among them, the best characterized are the naturally occurring CD4.CD25. regulatory T (Treg) cells, and the adaptive type 1 regulatory T (Tr1) cell

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Derivation, Culture, and Characterization of Thymic Epithelial Cell Linesls (TECs) is essential for development of central tolerance and for generation of the regulatory T-cell repertoire in the thymus. However, the mechanisms by which self-peptides are generated in and presented by TECs have not been well defined. To elucidate the processes involved in MHC class II-rest

言外之意

Thymus Organogenesis and Development of the Thymic Stromaed to generate a complex T-cell repertoire that is both self-tolerant and has propensity to bind self major histocompatibility complex. These processes depend on an array of functionally distinct epithelial cell types within the thymic stroma, which have a common developmental origin in the pharynge

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Studying T-Cell Repertoire Selection Using Fetal Thymus Organ Cultureibility complex (MHC) that present peptide on the surface of cells (MHC-restricted antigen recognition). However, the vast majority of T cells are tolerant to their own MHC molecules and do not give rise to autoimmune disease. This MHC-restricted, but tolerant, repertoire of T cells is determined by

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Gene Expression Profiling of Dendritic Cells by Microarray-tissue damage. The decision to activate an immune response is made by antigen-presenting cells (APCs) that are quiescent until they encounter a foreign microorganism or inflammatory stimuli. Early activated APCs trigger innate immune responses that represent the first line of reaction against invad

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SAGE Analysis of Cell Types Involved in Tolerance Inductionnd isolation of tolerant cell types and for monitoring the establishment of tolerance in in vivo models. Although high-affinity autoreactive T cells are deleted in the thymus during the establishment of central tolerance, escaping autoreactive cells require modulation in the periphery. Dendritic cel

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Analyzing the Physicodynamics of Immune Cells in a Three-Dimensional Collagen Matrixs to migrate and to interact with each other. Although observation of these phenomena in vivo would be the most physiological approach, intravital imaging is technically very demanding and not optimally suited for routine or high-throughput analysis. Any good in vitro experimental system should refl