Titlebook: Immunogenetics; Methods and Protocol Anton W. Langerak Book‘‘‘‘‘‘‘‘ 2022 The Editor(s) (if applicable) and The Author(s) 2022 The immunome.

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Adaptive Immune Receptor Repertoire (AIRR) Community Guide to Repertoire Analysis,ge, CDR3 properties, clonal lineage structure, and sequence diversity are all capable of revealing the dynamic immune response to perturbation by disease, vaccination, or other interventions. Here we focus on a conceptual introduction to the many aspects of repertoire analysis and orient the reader