Titlebook: Immunobiology of Proteins and Peptides—II; M. Z. Atassi Book 1982 The Editor(s) (if applicable) and The Author(s), under exclusive license

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Book 1982ns or non-proteins, whether they are self or non-self, takes place at the molecular-cellular interface through membrane receptor molecules that are proteins. The initial step of recognition activates a complex series of cellular events requiring some mechanism of cell-cell interactions and communi-

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The Use of Hybridoma Antibodies to Probe the Antigenic Determinants of Thyroglobulinroiditis is produced. Injection of large doses of MTg without adjuvant renders mice unresponsive to MTg, due to production of MTg-specific suppressor T cells.. Immunization with Tg under diverse conditions, therefore, may lead to autoantibodies alone, to both autoantibodies and thyroid lesions, or to suppression.

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Myoglobin-Reactive T Cell Clones., see below) and therefore occupy a central role . in controlling immune responsiveness, these techniques should provide both specific and generalized information relating to the immune responses to complex protein antigens.

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Analogy

The Major B and T Cell Determinant on Pigeon Cytochrome , in B10.A Mice native cytochrome . conformation were found to interact with B10.A anti-pigeon cytochrome . antibodies. Antibodies appear to recognize a determinant or determinants which overlaps with that which elicits the T cell proliferative response.

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Genetic Control of the Immune Response to Hemoglobin and its Subunits2. and H-2. mice are responders to the α-subunit and H-2., H-2. and H-2. mice are responsive to the β-subunit. The subunits are not cross-reactive in T-cell assays. Non-H-2 linked genes are also important in Hb-specific immunity. There is a requirement for Ly-1. T-cells for optimal responses in vitro.

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Antigen Bridging in the Interaction of T Helper Cells and B Cellsapten antibody response in animals primed separately with hapten and carrier, and the other involved thymus-marrow reconstitution of irradiated animals, demonstrating that hapten and carrier were recognized by different cell types in the anti-hapten antibody response.

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