Titlebook: Immunobiology of Natural Killer Cell Receptors; R.W. Compans,M.D. Cooper,Marco Colonna Book 2006 The Editor(s) (if applicable) and The Aut

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Transcriptional Regulation of NK Cell Receptors,ssion. An important question to be answered is whether or not the other NK cell receptor gene families contain probabilistic switches. The promoter elements currently identified in the Ly49, NKR-P1, CD94, NKG2A, and KIR gene families are described.

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NK Cell Activating Receptors and Tumor Recognition in Humans,owthemto recognize and kill transformed cells. The recent identification of some of the cellular ligands specifically recognized by these receptors/coreceptors contributes to elucidation of the mystery of the role played by NK cells in immune responses.

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Signal Transduction in Natural Killer Cells,ummarizes our knowledge of the intracellular mechanisms by which cell surface receptors influence biological responses by NK cells. Special emphasis focuses on the dynamic signaling events at the NK immune synapse and the unique signaling characteristics of specific receptors, such as NKG2D, 2B4, and KIR2DL4.

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Extending Missing-Self? Functional Interactions Between Lectin-like Nkrp1 Receptors on NK Cells witermed Clr, also encoded in the NKC. These genetically linked loci for receptor-ligand pairs suggest a genetic strategy to preserve this interaction and show several other contrasts with Ly49-MHC interactions. In this review, we discuss these issues and summarize recent developments concerning this non-MHC-dependent regulation of NK cell function.

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Immunobiology of Human NKG2D and Its Ligands,terns of constitutive tissue distributions have become apparent among members of one NKG2D ligand family. This review summarizes the biological properties of NKG2D and its ligands and discusses the interactions and regulation of these molecules with emphasis of their significance in microbial infections, tumor immunology, and autoimmune disease.

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Dendritic Cell-NK Cell Cross-Talk: Regulation and Physiopathology,and, reciprocally, on the consequences of NK cell activation on DC functions. The relevance of DC-NK cell cross-talk in the control of infectious diseases and tumor growth is discussed, highlighting the impact of this dialogue on the design of immunotherapy protocols.