Titlebook: Immunity, Tumors and Aging: The Role of HSP70; Igor Malyshev Book 2013 The Author(s) 2013 Age-related Diseases.Cardiovascular.Heat Shock P

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A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle, of heat shock proteins (HSP). In 1986 H. Pelham was the first to suggest that HSPs bind to denatured protein aggregates, thereby restricting their aggregation and breaking them by using ATP as an energy source. Among all HSPs, the protein with a molecular weight of 70?kDa was found to be the most c

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The Functions of HSP70 in Normal Cells,sm and provides protein transportation into organelles; (2) assisted by HSP40, HSP70 recognizes irreversibly damaged proteins and, assisted by CHIP, Bag-1 and HSJ1 ubiquitinates these proteins, thereby targeting them for degradation via proteasomes; and (3) together with the co-chaperones HSP90, HSP

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HSP70 in Aging,lls to reproduce and cope with stress. Important features of an aging cell include the progressive accumulation of damaged proteins, abnormal protein aggregates and oxidative stress. Such features may damage macromolecules and trigger two genetic programs—cellular senescence and apoptosis. HSP70 lim

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