Titlebook: Immune Hematology; Diagnosis and Manage Jenny M. Despotovic Book 2018 Springer International Publishing AG, part of Springer Nature 2018 im

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Presentation and Evaluation of Immune Thrombocytopeniaons often show severe thrombocytopenia, with variable to high mean platelet volume (MPV). In otherwise typical presentations, no additional testing is needed. The role of bone marrow testing remains controversial and is generally reserved for patients with an uncertain diagnosis or an atypical cours

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Background, Presentation and Pathophysiology of Autoimmune Hemolytic Anemiasenting manifestation of a myriad of underlying autoimmune, infectious and/or neoplastic processes, and awareness of such association allows for earlier diagnosis and management of these disorders. On the other hand, even isolated subclinical immune hemolysis can sometimes complicate the interpretab

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Pathophysiology of Thrombotic Thrombocytopenic Purpuraemic microthrombi; MAHA and schistocytosis develop as a result of mechanical fragmentation as the red blood cells cross these platelet thrombi. Microvascular endothelial injury in TTP is well described, but the pathophysiologic mechanisms for this injury are not well characterized. Proposed mechanis

Culmination

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Pathophysiology of Immune Thrombocytopenia light an increasingly complex web of interactions within the immune system which may be contributory. This chapter reviews what is currently known about the role of antiplatelet antibodies, cellular immunity, platelet production abnormalities, and genetics in the development and perpetuation of ITP.

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Intervention

Background and Pathophysiology of Autoimmune Neutropeniane neutropenia may present at any age with a more variable clinical course. Patients with the latter may have pan-FcγRIIIb autoantibodies and should undergo investigation for other autoimmune or primary immune system disorders.