Titlebook: Imaging Cell Signaling; Christoph Wuelfing,Robert F. Murphy Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive lic

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Alex X. Lu,Alan M. Mosese genes on brain development and structure remains unclear. Most current research was done on candidate gene polymorphisms and their possible associations with brain structural abnormalities in psychiatric diseases such as schizophrenia, major depressive disorder, and bipolar disorder. The polymorph

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Huangqingbo Sun,Robert F. Murphylarly visible during the most severe disease stages, these changes are more subtle at the prodromal stage, which is the moment when a clinical diagnosis should be ideally reached. A large body of research has tried to disentangle the nature of such modifications, modeling the regional anatomical var

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seline assessment to prognosticate the onset of psychosis in high-risk individuals is limited, great expectations were raised after implementing neuroimaging techniques as state-of-the-art research methodologies to find brain markers for clinical utility in emerging psychosis. However, although a tr

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Rapid Preparation of Living , Pupal Macrophages for Ex Vivo Imaging, at high spatiotemporal resolution within the intact, living animal. While optimized methods already exist to enable flow cytometry-based macrophage isolation from . at various stages of development, there remains a need for more rapid and gentle methods to isolate living macrophages for downstream

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Generation of 3D Fibroblast-Derived Extracellular Matrix and Analysis of Tumor Cell-Matrix Interactcer can impact the deposition of the matrix proteins, which can in turn act as an adhesion scaffold and signaling reservoir promoting disease progression. To study the composition and organization of the extracellular matrix as well as its interactions with (tumor) cells, this protocol describes the

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Design and Synthesis of DNA Origami Nanostructures to Control TNF Receptor Activation,signaling. Some strategies aim to cluster TNFR by using multivalent streptavidin or scaffolds based on dextran or graphene. However, these strategies do not allow for control of the valency or spatial organization of the ligands, and consequently control of the TNFR activation is not optimal. DNA or

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Controlling the Potency of T Cell Activation Using an Optically Tunable Chimeric Antigen Receptor,of great importance. While we know the components of many of the signaling networks that make these decisions, our understanding of the dynamic flow of information between these parts remains far more limited. T cells are an essential white blood cell type of an adaptive immune response and can disc

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Imaging Cell Signaling in Tissues Using the IBEX Method,tion of numerous pathways of interest simultaneously. Additional data can also be gained by placing the identified proteins into the context of adjacent structures, stroma, and interacting partners. Here, we outline a protocol for using the recently described IBEX method on tissues. This is an open

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