Titlebook: Idiopathic Pulmonary Fibrosis; Advances in Diagnost Hiroyuki Nakamura,Kazutetsu Aoshiba Book 2016 Springer Japan 2016 HRCT.IIP.IPF.KL-6.SP-

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Definition of IPFntral role for the diagnosis of IPF. The presence of UIP patterns on HRCT is essential and definitive in the diagnosis of IPF without the need for surgical lung biopsy (SLB). The revised 2011 criteria have emphasized the importance of multidisciplinary discussion between clinicians, radiologists, an

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Epidemiology and Risk Factors of IPFs, or senescence. Surfactant gene mutations induce endoplasmic reticulum (ER) stress response in epithelial cells, and telomere shortening induces epithelial cell apoptosis and senescence. The failure of tissue repair due to impaired homeostasis and deregulated immunological mechanisms leads to diso

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Pharmacotherapy of IPF Using Antifibrotic Compoundsveness in treating IPF. Because a substantial percentage of patients with IPF die from acute exacerbation or lung cancer, medical treatment for IPF should focus not only on slowing the disease progression, but also on reducing the risk of acute exacerbation and lung cancer. Further investigation reg

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Common Pathways in IPF and Lung Cancer the common pathogenesis of IPF and lung cancer and reviewed possible common pathways that are associated with both diseases. Besides common causative factors such as physical changes and environmental exposure, genetic modifications, epigenetic aberrations, and dysregulation in signaling pathways h