| 書目名稱 | IGFs:Local Repair and Survival Factors Throughout Life Span | | 編輯 | David Clemmons,Iain C.A.F. Robinson,Yves Christen | | 視頻video | http://file.papertrans.cn/461/460273/460273.mp4 | | 叢書名稱 | Research and Perspectives in Endocrine Interactions | | 圖書封面 |  | | 描述 | .Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer. . | | 出版日期 | Book 2010 | | 關(guān)鍵詞 | G proteins; ageing; cells; genes; growth; growth factor; growth hormone; hormone; insulin; insulin-like; metab | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-04302-4 | | isbn_softcover | 978-3-662-50583-0 | | isbn_ebook | 978-3-642-04302-4Series ISSN 1861-2253 Series E-ISSN 1863-0685 | | issn_series | 1861-2253 | | copyright | Springer-Verlag Berlin Heidelberg 2010 |
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