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Titlebook: Hypoxia in Cancer: Significance and Impact on Cancer Therapy; Sukhes Mukherjee,Jagat Rakesh Kanwar Book 2023 The Editor(s) (if applicable)

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發(fā)表于 2025-3-21 16:25:08 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Hypoxia in Cancer: Significance and Impact on Cancer Therapy
編輯Sukhes Mukherjee,Jagat Rakesh Kanwar
視頻videohttp://file.papertrans.cn/431/430814/430814.mp4
概述Explores the potential role of hypoxia in cancer progression and therapeutic response.Reviews the role of hypoxia-inducible factor in cancer progression.Presents association of hypoxia and microRNA an
圖書封面Titlebook: Hypoxia in Cancer: Significance and Impact on Cancer Therapy; Sukhes Mukherjee,Jagat Rakesh Kanwar Book 2023 The Editor(s) (if applicable)
描述This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.
出版日期Book 2023
關鍵詞Hypoxic tumor microenvironment; Tumor metastasis; Hypoxia-Inducible Factors; Cancer Immunotherapy; Non-C
版次1
doihttps://doi.org/10.1007/978-981-99-0313-9
isbn_softcover978-981-99-0315-3
isbn_ebook978-981-99-0313-9
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive licence to Springer Nature Singapor
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CRISPR/Cas9-Editing-Based Modeling of Tumor Hypoxia,pact. The effectiveness of new HIF-1 inhibitors is being sought after, and their effectiveness as anticancer therapies is being investigated. The HIF-1 transcription factor complex binds to hypoxia-responsive element (HRE) sequences found in the promoters of target genes to mediate the expression of
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Tumor-on-a-Chip: Microfluidic Models of Hypoxic Tumor Microenvironment,therapeutic, and screening. ToC microdevices, in particular, are competent for microscopic analysis of the interplay between tumors, immune, and cells in the TME, which are not amendable with simple tissue cultures or animal models. The difficulties in developing ToC tech for the next generation are
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Imaging the Hypoxic Tumor Microenvironment in Cancer Models,s, a number of molecular imaging systems have been progressed for hypoxia diagnostics in patients; these include invasive procedures like the use of oxygen polarographic electrode which measures tissue oxygen and phosphorescence quenching, noninvasive techniques such as magnetic resonance imaging (M
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Hypoxia-Targeting Drugs as New Cancer Chemotherapy Agents: Molecular Insights,he resistance to therapy. This has inspired cancer researchers to investigate the signal molecules for tumor hypoxia as potential molecular targets for cancer therapeutics. This chapter will overview various signaling pathways for hypoxia, its role in tumor proliferation, differentiation, progress i
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