Titlebook: Hypoxia and Cancer Metastasis; Daniele M. Gilkes Book 2019 Springer Nature Switzerland AG 2019 hypoxia.cancer.HIF.metastasis.angiogenesis

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Clinical and Pre-clinical Methods for Quantifying Tumor Hypoxia,e term hypoxia has two definitions. One definition would be a physiologic state where the oxygen partial pressure is below the normal physiologic range. For most normal tissues, the normal physiologic range is between 10 and 20?mmHg. Hypoxic regions develop when there is an imbalance between oxygen

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Hypoxia and the Tumor Secretome,ic options will become available only if we enhance our understanding of mechanisms underlying metastatic spread. A large body of literature shows that the metastatic potential of tumor cells is strongly influenced by microenvironmental cues such as low oxygen (hypoxia). Clinically, hypoxia is a hal

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Hypoxia and Metabolism in Metastasis, a large number of target genes involved in cell growth, metabolism, metastasis and immunity are activated in cancer cells. Hypoxia-inducible factor 1 (HIF-1), as a heterodimeric DNA-binding complex, is comprised of a constitutively expressed HIF-1β subunit and an oxygen sensitive HIF-1α subunit, th