Titlebook: Hypoxia and Cancer Metastasis; Daniele M. Gilkes Book 2019 Springer Nature Switzerland AG 2019 hypoxia.cancer.HIF.metastasis.angiogenesis

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Hypoxia Mediates Tumor Malignancy and Therapy Resistance,reprogramming, immune evasion, pH homeostasis, cell migration/invasion, stem cell pluripotency, and therapy resistance. In this book chapter, we reviewed the causes and types of intratumoral hypoxia, hypoxia detection methods, and the oncogenic role of HIF in tumorigenesis and chemo- and radio-therapy resistance.

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Bibliothek des Radio Amateurs (geschlossen)demonstrated an important functional role for HIF signaling in driving CSC, metastatic and drug resistant phenotypes . and .. Here we will review recent studies that highlight novel mechanisms by which hypoxia promotes cancer stem cell, metastatic and drug resistant phenotypes.

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Kurt Hesse,Rolf Fraling,Wolfgang Fralinganisms by which intratumoral hypoxia regulates the expression of motogenic and mitogenic factors that induce angiogenesis and lymphangiogenesis, whilst discussing their implications for metastatic cancers.

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Hypoxia and Metabolism in Metastasis,us, adapts to decreased oxygen availability as a transcriptional factor. HIF-1 regulates many genes involved in tumorigenesis. Here, we focus on cancer cell metabolism and metastasis regulated by hypoxia.

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