Titlebook: Hypoxia and Cancer; Biological Implicati Giovanni Melillo Book 2014 Springer Science+Business Media New York 2014 cancer.microenvironment.t

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書目名稱Hypoxia and Cancer影響因子(影響力)




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禁令

Hypoxia and Reactive Oxygen Speciesrobic metabolism but also as important signaling molecules in various physiological and pathophysiological conditions. This has broadened the field of oxygen signaling in a substantial way given the fact that superoxide is derived from molecular oxygen. In this regard ROS and ROS-dependent signaling

Insubordinate

Microgram

Carbonic Anhydrase IX: From Biology to Therapy of adaptive transcriptional changes mediated primarily by the hypoxia-inducible factor (HIF), and via stimulation of ion transport machinery maintaining normal intracellular pH. In addition, through these adaptive responses tumor cells acquire new features endowing them with selective advantage in

要素

jaunty

Clinical Imaging of Hypoxiao be a source of resistance to conventional therapy, especially radiation and certain types of chemotherapy. Such hypoxic cells also play an important role in influencing malignant progression in terms of both enhancing growth of the primary tumour and increasing metastatic spread. Numerous attempts

meretricious

拖網(wǎng)

The Unfolded Protein Response and Therapeutic Opportunitiesent, including hypoxia. Although the most studied cellular signaling pathway induced by hypoxia is mediated by the transcriptional activity of hypoxia-inducible factors (HIFs), several HIF-independent mechanisms have been implicated in hypoxic adaptation, especially in the regulation of macromolecul