Titlebook: Hypoxia; Translation in Progr Robert C. Roach,Peter H. Hackett,Peter D. Wagner Book 2016 The Editor(s) (if applicable) and The Author(s), u

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https://doi.org/10.1057/9781137375544functioning is matched to the activity level of neurons. Although the close relationship of brain glia known as astrocytes with cerebral blood vessels has long been recognized, it is only recently that these cells have been demonstrated to translate information on the activity level and energy deman

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Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence r and metabolic disease in adulthood. These observations have led to the so-called developmental origin of adult disease hypothesis. More recently, evidence has been provided that the pulmonary circulation is also an important target for the developmental programming of adult disease in both experim

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Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in a failure to target disease abnormalities that are distinct from processes vital to normal cells. NSCLC and PAH share reversible mitochondrial-metabolic abnormalities which may offer selective therapeutic targets. The following mutually reinforcing, mitochondrial abnormalities favor proliferation,

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Why Are High-Altitude Natives So Strong at Altitude? Maximal Oxygen Transport to the Muscle Cell in are reported to have higher maximal oxygen uptake (VO.max). The likely basis for this is a higher pulmonary diffusion capacity, which in turn ensures higher arterial O. saturation (SaO.) and therefore also potentially a higher delivery of O. to the exercising muscles. This review focuses on O. tran

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Functional Genomic Insights into Regulatory Mechanisms of High-Altitude Adaptationidentify candidate loci for hypoxia adaptation. When integrated with experimental analyses of physiological phenotypes, genome-wide surveys of DNA polymorphism and tissue-specific transcriptional profiles can provide insights into actual mechanisms of adaptation. It has been suggested that adaptive