| 書目名稱 | Hydrogen Sulfide and its Therapeutic Applications | | 編輯 | Hideo Kimura | | 視頻video | http://file.papertrans.cn/431/430399/430399.mp4 | | 概述 | Gives a broad overview to the topic from chemical and biochemical basics to therapeutic application.First volume on the topic with interdisciplinary scope.Respective topics discussed by experts in bas | | 圖書封面 |  | | 描述 | The metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900’s.? Three enzymes, cystathionine β–synthase (CBS), cystathionine γ–lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H.2.S in vitro.? However, H.2.S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule.?? In the late 1980’s relatively high concentrations of sulfide were measured in the brain that led to the successive studies of identifying the physiological functions of H.2.S. ?Recently, the steady-state concentrations of H.2.S have been re-evaluated and found to be much less than that initially measured.? However, despite these differences, such re-evaluations served to further confirm the existence of H.2.S in mammalian tissues.? H.2.S is produced in almost every organ and plays various roles such as neuromodulation, vasodilation, insulin release, inflammation, angiogenesis and cytoprotection. The unregulated production of H.2.S and improper responses of target molecules are involved in the pathogenesis of various disea | | 出版日期 | Book 2013 | | 關(guān)鍵詞 | inflammation; neuromodulation; sulfur metabolism; sulfur transferase | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-7091-1550-3 | | isbn_softcover | 978-3-7091-1974-7 | | isbn_ebook | 978-3-7091-1550-3 | | copyright | Springer-Verlag Wien 2013 |
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