Titlebook: Hybrid Systems Biology; 6th International Wo Milan ?e?ka,Nicola Paoletti Conference proceedings 2019 Springer Nature Switzerland AG 2019 co

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lanugo

ons in design of industrial technological processes and the understanding the structure and the intermolecular interactions in the systems. On the basis of classical thermodynamics the measured experimental data combined together enable us the calculation of non-measurable thermodynamic properties s

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Fixed-Point Computation of Equilibria in Biochemical Regulatory Networksequilibria, with the guarantee of yielding the unique equilibrium of the ODE in the case that the returned set is a singleton. We demonstrate the applicability of our algorithm to two signaling pathways of MAPK and EGFR.

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Rejection-Based Simulation of Stochastic Spreading Processes on Complex Networks computationally very expensive..Here, we propose a novel simulation approach, which combines the advantages of event-based simulation and rejection sampling. Our method outperforms state-of-the-art methods in terms of absolute runtime and scales significantly better while being statistically equivalent.

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敏捷

Hybrid Modeling of Metabolic-Regulatory Networks (Extended Abstract)latory network model (MRN) that allows integrating metabolism with transcriptional regulation, macromolecule production and enzyme resources. Using this model, we show that the dynamic interplay between these different cellular processes can be formalized by a hybrid system, combining continuous dynamics and discrete control.

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Reachability Analysis and Hybrid Systems Biology - In Memoriam Oded Maler greatly progressed in recent years. This discussion is not intended to include an exhaustive survey of the existing results (The reader is referred to the recent proceedings of the conferences Hybrid Systems: Computation and Control.) but to show the strong impact of his foundational work.

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