Titlebook: Hybrid Systems Biology; 5th International Wo Eugenio Cinquemani,Alexandre Donzé Conference proceedings 2016 Springer International Publishi

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tional scientists.Also available online in www.springerlink..Heat of mixing data are important to the design of industrial processes. They can be used in energy balance and phase equilibrium calculations. Being related to the structure and the energy of interaction of the molecules in the pure subst

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Matej Hajnal,David ?afránek,Martin Demko,Samuel Pastva,Pavel Krej?í,Lubo? Brim related to the structure and the energy of interaction of the molecules in the pure substances and in the mixtures, heat of mixing data are of paramount importance also from the theoretical point of view. ..This subvolume containes selected data on heats of mixing (excess enthalpies) of binary liqu

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A Look-Ahead Simulation Algorithm for DBN Models of Biochemical Pathwayste well the dynamics of biochemical models, while offering improved efficiency for their analysis [., .]. In this paper, we compare different representations and simulation schemes on these DBNs, testing their efficiency and accuracy as abstractions of biological pathways. When generating these DBNs

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Accelerated Simulation of Hybrid Biological Models with Quasi-Disjoint Deterministic and Stochastic aditional simulators become inefficient to tackle emerging computational challenges. Hybrid simulation, which combines deterministic and stochastic parts, is a promising direction to deal with such challenges. However, currently existing algorithms of hybrid simulation are impractical for implementi

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Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathwaysnome by means of regulation of specific genes expression. In this short paper, we provide a preliminary study targeting minimal models representing the topology of main signalling mechanisms. A special emphasis is given to distinguishing between monotonous (sustained) and non-monotonous (transient)

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Application of the Reachability Analysis for the Iron Homeostasis Studyis a characterization of the parameters space such that the model satisfies a set of constraints, proposed by biologists or coming from experimental results. We now propose an approach to hypothesis validation which can be seen as a complement to the approach based on simulation. It uses reachabilit

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Synchronous Balanced Analysiss. We aim to substitute to a Chemical Reaction Network, especially a “growth” one (i.e., for which an exponential stationary phase exists), a piecewise synchronous approximation of the dynamics: a resource-allocation-centered Petri Net with maximal-step execution semantics. In the case of unimolecul

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Verification of Temporal Properties of Neuronal Archetypes Modeled as Synchronous Reactive Systemsn be associated with specific classes of biologically relevant structures and behaviors. These archetypes are supposed to be the basis of typical instances of neuronal information processing. To model different representative archetypes and express their temporal properties, we use a synchronous pro