Titlebook: Hyaluronan; Structure, Biology a Alberto Passi Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive license to Spring

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n of a?given gene, with a?triplex formingoligonucleotide (TFO), realizing a?triple helix complex (triplex), with the aim of down-regulatinggene expression. This chapter describes the basic principles of the triplex approach, the chemistry underliningthe binding of daunomycin to oligonucleotides, and