Titlebook: Huntington’s Disease; Sophie V. Precious,Anne E. Rosser,Stephen B. Dunne Book 2018 Springer Science+Business Media, LLC, part of Springer

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,Minipigs as a Large-Brained Animal Model for Huntington’s Disease: From Behavior and Imaging to Gen. Challenges in the development of, for example, gene therapy, such as delivery, distribution, and persistence of virus vectors or oligo sense nucleotides, can be explored in large brains and organisms approaching human size. We here introduce the transgenic Libechov minipig as a large animal model

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,In Vivo Multidimensional Brain Imaging in Huntington’s Disease Animal Models,tingtin protein. This mutation induces the expression of a polyglutamine stretch in the mutated protein resulting in the modification of various biological properties of the wild-type protein and the progressive appearance of motor, cognitive, and psychiatric disorders that are typically associated

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,Magnetic Resonance Imaging in Huntington’s Disease,ulation of radio waves and static field gradients, MRI uses the principle of nuclear magnetic resonance to produce images with high spatial resolution, appropriate for the investigation of brain structure and function.

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,Assessing and Modulating Kynurenine Pathway Dynamics in Huntington’s Disease: Focus on Kynurenine 3. Several novel genetic and pharmacological tools have recently been developed to modulate key regulatory steps in the KP such as the reaction catalyzed by the enzyme kynurenine 3-monooxygenase (KMO). This insight has offered new options for exploring the mechanistic link between this metabolic path

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,Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington’s Disease, with mitochondria in a deleterious manner. As the central hub of the cell, not only mitochondrial bioenergetics is affected but there is also diminished mitochondrial membrane potential (Δ..) and altered production of reactive oxygen species (ROS). Restoration of mitochondrial function has proven t

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Mariah J. Lelos,Stephen B. Dunnettnd consists of two lists (alphabetical by compounds), one for Curie and one for Neel temperatures. Where different values appeared in the literature for a single compound, all are listed with sepa- rate references given for each. There is no attempt at critical evaluation, which, except for a few we