Titlebook: Human Tumour Xenografts in Anticancer Drug Development; Benjamin Winograd,Michael Peckham,Herbert Michael Conference proceedings 1988 Spr

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Biology of Human Ovarian Cancer Xenografts1% of all specimens could be transferred beyond 3 passages. Transplantability was most successful if samples were derived from a metastatic lesion, contained a high number of mitotic figures and were not infiltrated by lymphocytes. The take rate was not dependent on the histologic subtype or the deg

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Comparison of Tumor Response in Nude Mice and in Patients obtained in 79%, rapid tumor growth after 3 months in 51%, and 49% of these tumors were transferred in serial passages. Most of the latter tumors were suitable for drug testing. In order to investigate whether tumor response in nude mice is consistent with patient response, 80 comparisons were perf

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Lung Xenografts as a Predictive Screen for Antineoplastic Agentstumour categories and the various histological types. From the 131 tumours growing in primary transplants, 80 tumours could be established as lines. In order to examine whether growth characteristics of untreated tumours in nude mice might be of prognostic significance for patient survival, the data

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Chemotherapy Studies in Human Non-Small Cell Lung Cancer Xenografts Transplanted in Immune-Deprived squamous carcinoma. The overall take rate of all tumour fragments implanted in the first man to mouse passage was low (10%) but this improved in subsequent passages to 57%. Growth rates were variable in all xenografts. Histopathological features were maintained through the first 7 passages although

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