Titlebook: Human Epigenomics; Carsten Carlberg,Ferdinand Molnár Textbook 2018 Springer Nature Singapore Pte Ltd. 2018 Epigenomics in Cancer.Epigenomi

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Chromatin Remodelers and Organizersssion. Chromatin accessibility is controlled by DNA methylation, histone modifications and chromatin modifiers, but also chromatin remodeling and 3D chromatin organization are relevant in this process. Chromatin remodelers are multi-protein complexes that use the energy of ATP hydrolysis, in order t

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Cancer Epigenomicsmal cells cancer cells show genome-wide changes in DNA methylation, histone modifications and 3D chromatin structure. In addition, many tumors re-activate programs of fetal development, which is a sign of epigenetic reprograming. The mechanistic bases of cancer epigenomics are specific genetic, envi

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Neuroepigeneticsd methylome reconfiguration, such as non-CG methylation (mCH), occurs in neurons, but not in glial cells, during fetal to young adult development and becomes the dominant form of methylation in the human neuronal genome. In parallel, during brain development, there is an increase of 5hmC marks and p

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Nutritional Epigenomicsnditions. Metabolic pathways communicate with chromatin and provide information about nutrient availability and energy status via the levels of key metabolites, such as AMP, NAD., SAM and acetyl-CoA. These metabolites act as co-factors and substrates of chromatin modifiers, such as KMTs, KATs, KDACs