Titlebook: Human Epigenetics: How Science Works; Carsten Carlberg,Ferdinand Molnár Textbook 2019 Springer Nature Switzerland AG 2019 Genetics.Inherit

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Histone Modifications,e acetylations and methylations of histone tails have a large functional impact. Genome-wide profiling of the large set of post-transcriptional histone modifications provides the basis of the histone code. This code leads to the understanding, how the epigenome directs transcriptional regulation and stores information.

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Introduction,e responds to intra- and extra-cellular signals . changes in DNA methylation and histone modifications. Accordingly, the epigenetic landscape visualizes epigenomic changes during cellular differentiation, tumorigenesis and other cellular perturbations. Thus, ..

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Chromatin,regulatory layers (., dimensions) of chromatin range from single nucleosomes . looping of genomic regions to large-scale folding of whole chromosomes into territories within the nucleus. The accessibility of the chromatin at enhancer and promoter regions determines whether a gene is expressed or not

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Chromatin Modifying Proteins and RNAs, the epigenome. Antagonizing enzymes, such as HATs and HDACs, often co-localize at chromatin regions and fine-tune gene expression. Chromatin modeling complexes change the structure of chromatin by shifting, evicting or replacing nucleosomes. Finally, also long ncRNAs, such as ., can affect chromati

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Embryogenesis and Cellular Differentiation, epigenetics has the largest impact. Epigenetics directs the programing of PGCs, induced pluripotency as well as the function of adult stem cells in tissue homeostasis. These master examples demonstrate the impact of epigenetics on the organization of our body in health and disease.