Titlebook: Human Apolipoprotein Mutants III; Diagnosis and Treatm Cesare R. Sirtori,Guido Franceschini,Bryan H. Brew Conference proceedings 1993 Sprin

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1010-8793 drugsand their possible clinical use for vascular and nonvascular disease is discussed and finally an overview onlipoprotein transformationprocesses, expression systems andnatural mutants is provided.978-3-642-84636-6978-3-642-84634-2Series ISSN 1010-8793

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Apolipoprotein B: Genetic Variants Provide Insight into Structure and Functionf our understanding of the structure-function aspects of apo B have come from studies of rare genetic variants. Several genetic disorders of lipoprotein metabolism are directly linked to the apo B gene or associated with the biosynthesis, assembly or secretion of apo B containing lipoproteins.

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Conference proceedings 1993fertilization programs,neurological or inflammatory disorders, and the like.However, these young members of the large family ofcirculating proteins still deserve careful study, both interms of structural and functional properties and of theirpathological changes. In addition, related molecules, inpa

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Structural and Functional Properties of Apo A-I Variants in Reconstituted HDLlipid transfers, and in the binding of HDL to cell surfaces. More than 20 natural mutants of apo A-I are known (von Eckardstein et al., 1990); most of these mutants are not associated with detectable disease states nor abnormalities in lipid metabolism; nevertheless, they may provide interesting insights into the structural properties of apo A-I.

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