Titlebook: Human Apolipoprotein Mutants; Impact on Atheroscle C. R. Sirtori,A. V. Nichols,G. Franceschini Book 1986 Springer Science+Business Media Ne

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DNA Polymorphisms and Analysis of Hyperlipidaemiaate genes that are known to be involved in the metabolism of cholesterol and triglycerides. Even though the list is not comprehensive, there is clearly a problem of how to decide which genes to study first. Some of the candidates, such as the LDL receptor, are already clearly implicated and warrant

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Apolipoprotein AI-Milano: A Structural Modification in an Apolipoprotein Variant Leading to Unusual ano (AI.) mutant was identified in an Italian family.. The apo E mutants are often associated with severe hyperlipidemia, primarily dysbetalipoproteinemia, and premature atherosclerosis. By contrast, with the exception of the apo AI., there is no convincing evidence M associating any of the describe

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The AI-Milano HDL Particles correlation with the risk of arterial disease (1,2). Based on such observations, an increased incidence of premature disease would be expected in individuals with very low levels of HDL. Surprisingly, several rare familial disorders characterized by decreased levels of HDL do not show the presence

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The Limone Sul Garda GeneBarr et al., 1951; Gofman et al., 1966; Miller & Miller, 1975; Gordon et al., 1977). The mechanism by which they confer protection against atherosclerosis is unclear. . experiments involving isolated erythrocytes and cultured cells suggest that HDL may be involved in the delivery of cholesterol from