Titlebook: Hormones in Ageing and Longevity; Suresh Rattan,Ramesh Sharma Book 2017 The Editor(s) (if applicable) and The Author(s), under exclusive l

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How Hormones, as Ancient Signalling Molecules, Regulate Diverse Biological Processes Through Evolutiion and programmed cell death in unwanted tissues in the tail and intestine. The acquisition of hormonal function during evolution is likely to have coincided with the appearance of hormonal receptors, which are the key to understanding the mechanism or specificity of action of a given hormone. The

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Somatotropic Axis’ Role in Ageing and Longevity Could Depend on Life-History Strategies of Species, modulating the somatotropic axis would probably not increase human lifespan, because increased lifespan has not been selected as a strategy: how a genetic pathway could modulate lifespan in the absence of any selective pressure?

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Zinc, Insulin and IGF-I Interplay in Agingnd IIS on the modulation of longevity appears to be still unclear and characterized by contradictory findings, there is consistent support to draw a picture where a functional cell is able to disentangle IIS-mediated “nutritional Zn signals”, which activate growth promoting pathways, functional inte

relieve

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Liberate

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Melatonin in Healthy Aging and Longevitycal studies have documented a remarkable neuroprotective potential. Despite encouraging results, the translation of findings to the human is sometimes problematic, e.g., because of the different association of melatonin with rest or activity in nocturnally active rodents and in man. These difference

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Estrogens in Ageingbrain estrogens protect against insult-induced neuronal damages. Ageing is an inevitable process where brain undergoes structural, physiological and functional changes. During ageing, level of estrogen, ERs and binding of transcriptions factors to ER promoter decline with age. Moreover, the expressi