Titlebook: Hormonally Active Brain Peptides; Structure and Functi Kenneth W. McKerns,Vladimir Panti? Book 1982 Springer Science+Business Media New Yor

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The Search for the Active Center of the Gonadotropins,ypeptide hormones do not enter the target cell. However, this theory cannot accommodate the newly published data showing the entry of the tropic hormones into their target cells with an activation of enzymes in the cytoplasm and chromatin. Petrusz (1978) has discussed this intracellular action of gonadotropins.

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In Vitro Release of Luteinizing Hormone-Releasing Hormone,9) and are not discussed as extensively or intensively here as there. In this report we use conclusions from these reviews to develop a model for the control of gonadotropin secretion, one aspect of gonadal steroid action in the brain, and to extend our knowledge of this system by studying potential perturbants of the neuroendocrine axis.

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,Effects of Estrogens on Receptor “Nucleotropy” and “Activation”,stants of association are in the 10. M. range. Receptors bind “their” steroid with high specificity. These properties are shown by all receptors, independent of their tissue of origin. Furthermore, the accumulation of steroid-receptor complexes in the nucleus, the site of action, is common to all target cells.

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Distribution and Changes in Peptides in the Brain,not all of these are as yet firmly established as classical neurotransmitters, the physiological roles of certain peptides, in particular the opiate peptides, and their interactions with other systems in the brain are beginning to be understood.

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Studies on the Conformation of Neuropeptides,nteraction, metabolism) is devoted to studies of their precise three-dimensional structure. Most biologically active peptides have been investigated with varying intensity, thoroughness, and follow-up as to their solution conformation and its possible significance for biological activity.

MUTED

The Search for the Active Center of the Gonadotropins,ng in the cell membrane leading to the activation of adenylate cyclase and an increase in cyclic AMP. The cyclic AMP binds to a regulatory subunit of a cyclic AMP-dependent protein kinase, leading to the activation and release of the subunit. The activated protein kinase is believed to be the mediat

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Hormonal Regulation of and Ionic Requirements for in Vitro Release of Hypothalamic Peptides,highly concentrated in hypothalamic areas important for neuroendocrine control (Vale ., 1980; Elde and H?kfelt, 1978). Overlapping anatomical distributions (H?kfelt ., 1980; Elde and H?kfelt, 1978; Fuxe, 1965) of several neuropeptides and neurotransmitters within these hypothalamic areas made it tem