Titlebook: Hormonal Control of Cell Cycle; Shlomo Melmed,Henri Rochefort,Yves Christen Conference proceedings 2008 Springer-Verlag Berlin Heidelberg

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Deciphering the Conundrum of Estrogen-driven Breast Cancer: Aurora Kinase Deregulation, 90% of all breast cancer cases are sporadic/non-familial, and largely ductal carcinomas.Estrogens have a profound role in BC causation and progression.Although estrogen receptor α is an important characteristic of BC, it is not its most defining feature.Rather, its hallmark is chromosomal instabili

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Pituitary Trophic Status as a Tumorigenic Determinant, Hormone secreting anterior pituitary cells exhibit slow turnover rates. Subsequent postnatal alterations in pituitary size are determined throughout the lifespan by both extrinsic and intrinsic factors. PTTG, a mammalian securin protein is overexpressed in several endocrine (pituitary, thyroid, bre

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Estrogens, Cell Proliferation and Breast Cancer, of three proto-oncogenes (c-Myc, cyclin D1 and cyclin E1) that are rate limiting for normal G1 to S phase cell cycle transition. Mammary epithelial cell-specific overexpression of these genes induces mammary carcinoma in mice. Furthermore, c-Myc, cyclins D1 and E1 are commonly overexpressed in prim

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Marcel Méchaliultaneous development of new machining techniques. Those new techniques are often referred to as “non-traditional” in contrast to the “traditional” metal-cutting processes such as turning, milling or grinding. Most of them are characterized by a material-removal process based on physical or chemical