Titlebook: Hormonal Carcinogenesis V; Jonathan J. Li,Sara A. Li,Thierry Maudelonde Book 2008 The Editor(s) (if applicable) and The Author(s), under e

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Prostate Cancer Susceptibility Loci: Finding the Genesisease (1). Although there is considerable variability in disease incidence by age, race, and family history, about 70% of all cases are ≥65 years (yrs) at diagnosis, and the median age at diagnosis in the USA is 68 yrs (2). The disease is more frequent among African American (AA) than Caucasians; A

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Regulation of Hormone Signaling by Nuclear Receptor Interacting Proteinsion function (AF1 and AF2, respectively), the latter being associated with the ligand-binding domain. These activation functions act independently or synergistically depending on the cell type and promoter context, by recruiting a number of cofactors (2).

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Prostate Cancer Susceptibility Loci: Finding the Geness) at diagnosis, and the median age at diagnosis in the USA is 68 yrs (2). The disease is more frequent among African American (AA) than Caucasians; Asian men have the lowest reported incidence (3, 4).

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