| 書(shū)目名稱(chēng) | Hormonal Carcinogenesis IV | | 編輯 | Jonathan J. Li (Profesor of Pharmacology, Toxicolo | | 視頻video | http://file.papertrans.cn/429/428279/428279.mp4 | | 概述 | Covers a group of hormonally-associated cancers that present interesting challenges to clinicians and biomedical researchers.Addresses vital questions that impact our understanding of the causation, d | | 圖書(shū)封面 |  | | 描述 | It has been over a decade since the First International Symposium on Hormonal Carcinogenesis convened in 199 1. Since then, the field has rapidly expanded with considerable progress in both breast and prostate cancers; while ovarian and endometrial cancer have been hampered, in part, due to the absence of suitable hormone-mediated animal models. While knock-out, transgenic, and cell-culture systems have been extremely useful in identifying specific genelprotein alterations and the ensuing pathways affected, the precise molecular mechanisms whereby sex hormones elicit their oncogenic effects still remain elusive. Moreover, despite the considerable progress made in breast cancer research, the exact role of progestins in the presence or absence of estrogen in breast growth, differentiation, and malignant transformation is lacking. Elucidating the incipient molecular alterations in earlylpre-invasive lesions elicited by these hormones is a growing important focus of this field. The main purpose of these Symposia has been to address vital questions that impact our understanding of the causation, dependency, progression, resistance, and prevention of hormonally-associated cancers. We are | | 出版日期 | Book 2005 | | 關(guān)鍵詞 | biology; cancer; carcinogenesis; cell; endometrium; hormones; liver; metabolism; molecular biology; ovarian c | | 版次 | 1 | | doi | https://doi.org/10.1007/b102371 | | isbn_ebook | 978-0-387-23761-9 | | copyright | Springer-Verlag US 2005 |
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