Titlebook: Histocompatibility Antigens; Structure and Functi P. Parham,J. Strominger Book 1982 Springer Science+Business Media Dordrecht 1982 Plantati

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Crayon

Involvement of Self in the Interactions of Lymphocytes and Target Cells: Some Speculations on the Ns a single receptor specific for some associative interaction between virus and H-2 antigen. The idea that the T cell may express a single, two-chain receptor which recognizes a virus-H-2 complex is claimed by proponents of both models. The concept that, if there are two components to the receptor(s

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MHC-Linked Complement Components,s in complement activity stimulated searches for asspciations of complement components with MHCs in other mammalian species, which were subsequently detected (cf. Alper, 1980). Evidence from man and the guinea pig clearly indicates control, by regions of the MHC, of at least two early components of

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Book 1982determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this

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tic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this 978-94-009-5896-8978-94-009-5894-4

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early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prom

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The Interaction of MHC Antigens with the Plasma Membrane and the Other Cellular Components,ouse and HLA-Dr in man, stimulate mixed lymphocyte cultures and graft versus host reactions. Recognition of Ia antigens is involved in T cell-macrophage and T cell-B cell interactions. The involvement of Class I and Class II antigens in lymphocyte interactions leading to immune responses is discussed in Chapters 4 and 5 of this volume.