Titlebook: Histamine Receptors; Preclinical and Clin Patrizio Blandina,Maria Beatrice Passani Book 2016 Springer International Publishing Switzerland

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Hiroyuki Fukui M.D., Ph.D.,Hiroyuki Mizuguchi,Yoshiaki Kitamura,Noriaki Takedattel. Hauptkostentreiber waren Onkologika (9,5?Mrd. €, + 12,4?%)und Antidiabetika (2,8?Mrd. €, + 16,8?%). Ein wesentlicher Grund für die Kostenprobleme ist der seit Jahren beobachtete Anstieg der Jahrestherapiekosten neu eingeführter Arzneimittel. Dieser Trend zu hochpreisigen Patentarzneimitteln is

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The Role of Histamine H4 Receptor in Asthma and Atopic Dermatitis, dermatitis. Therefore, the histamine H. receptor may play a role in diseases such as asthma and atopic dermatitis, which have long since been believed not to be mediated by histamine due to lack of efficacy of traditional antihistamines.

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Clinical Significance of Histamine H1 Receptor Gene Expression and Drug Action of Antihistamines,s for transcriptional control elements including AP-1, ETS-1, and Ku86/Ku70 complex were located in the H1R gene promoter region. Similar to the antihistamines, improvement of nasal symptoms and suppression of H1R mRNA were observed in nasal hypersensitivity in rat models by the pretreatment with .

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Histamine and Its Receptors as a Module of the Biogenic Amine Diseasome,ence of a biochemical imbalance in one or more tissues, the physiological importance of these compounds and their multiple relationships must have a reflection in the human ., the scope of which is not yet known. This fact impedes development of new solutions for diagnosis, prognosis, and treatment

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Interaction of Brain Histaminergic and Dopaminergic Systems, involved in the regulation of reward too. The midbrain areas where dopaminergic neuron somas are located, substantia nigra and ventral tegmental area, also receive histaminergic projections [2, 3]. Of importance, the striatum expresses a high density of histamine H1–H3 receptors [4–6] suggesting th