Titlebook: Hirschsprung‘s Disease and Allied Disorders; Alexander Matthias Holschneider,Prem Puri Book 20083rd edition Springer-Verlag Berlin Heidelb

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,Neurocristopathies and Particular Associations with Hirschsprung’s Disease,ytes, adrenal medulla cells, C cells of the thyroid, sympathetic ganglia and the enteric nervous system (ENS) of visceral ganglia, sensory tracts of cranial and spinal nerves, as well as the membranous bones of the face and palate.

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Functional Diagnosis,Besides aganglionosis, there is no clear correlation between histomorphology and function of the bowel. Therefore functional diagnosis of chronic constipation is of great importance for the diagnosis and treatment of Hirschsprung’s disease (HD) and allied disorders.

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Immunohistochemical Studies,Several diagnostic methods are necessary in the examination of patients in whom Hirschsprung’s disease (HD) is suspected. These are clinical examination, contrast enema, anorectal manometry and rectal biopsy. It has been shown that rectal suction biopsies (RSB) have the highest sensitivity (93%) and specificity (100%) rates in diagnosing HD.

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,Histopathological Diagnosis and Differential Diagnosis of Hirschsprung’s Disease,ot be established by an H&E staining or immunohistochemical reaction. In contrast to immunohistochemistry or H&E staining, the introduction of the enzyme histochemical acetylcholinesterase reaction (AChE) has made the morphological diagnosis of HD easier and more reliable [12, 19, 20, 31].

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n laparoscopic approach.Includes supplementary material: ."Hirschsprung‘s Disease and Allied Disorders" is the third edition of a comprehensive study of the neuronal disorders of the lower gastrointestinal tract in children. Important new studies and progress in research on bowel motility and motili

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