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Titlebook: Hirschsprung‘s Disease and Allied Disorders; Prem Puri Book 2019Latest edition Springer Nature Switzerland AG 2019 Hirschsprung’s Disease

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樓主: Holter-monitor
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發(fā)表于 2025-3-26 22:01:28 | 只看該作者
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發(fā)表于 2025-3-27 13:02:46 | 只看該作者
,Genetics of Hirschsprung’s Disease,s attributed to a disorder of the enteric nervous system (ENS) whereby ganglion cells fail to innervate the lower gastrointestinal tract during embryonic development. HSCR is a complex disease that mainly results from the interaction of several genes and manifests with low, sex-dependent penetrance
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發(fā)表于 2025-3-28 00:37:29 | 只看該作者
,Epidemiology and Clinical Characteristics of Hirschsprung’s Disease,ls in the distal bowel beginning at the internal sphincter and extending proximally for varying distances. In the human fetus, neural crest-derived neuroblasts first appear in the developing esophagus at 5?weeks of gestation and then migrate down to the anal canal in a craniocaudal direction during
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發(fā)表于 2025-3-28 05:18:46 | 只看該作者
,Congenital Anomalies and Genetic Associations in Hirschsprung’s Disease, of normal signalling during development of enteric nerve cells, resulting in aganglionosis of the distal bowel. It is a frequent cause of neonatal intestinal obstruction and beyond..It occurs as an isolated phenotype in 70% but is not infrequently associated with congenital abnormalities (5–32%) an
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