Titlebook: Highly Selective Neurotoxins; Basic and Clinical A Richard M. Kostrzewa Book 1998 Springer Science+Business Media New York 1998 Neuroscienc

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MPTP,pread recognition. Rather, the spectacular way that its biologic effects were first recognized, which was a direct result of the clandestine manufacture of illicit drugs (.), thrust this previously obscure compound squarely into the limelight. Although in retrospect at least one earlier case had bee

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Haloperidol-Derived Pyridinium Metabolites,oleptics, drugs that are characterized by their antagonist properties at the dopamine (DA) D2-receptor, has allowed most schizophrenic patients to be treated on an outpatient basis. These drugs remain the cornerstone in the management of these patients. The two principal classes of “typical” neurole

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The Neurotoxic Effects of Continuous Cocaine and Amphetamine in Habenula,represent a different approach to neurotoxicology than most studies in this area. One might be drawn toward toxicological studies of brain for a variety of reasons. One would be the attempt to determine what agents in the environment have toxic effects; this line of research would eventually focus o

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Evidence for and Mechanism of Action of Neurotoxicity of Amphetamine Related Compounds,, discuss critical determinants of AMPH neurotoxicity, and consider possible mechanisms underlying the neurotoxic action of AMPH and some of its derivatives. This evidence indicates that METH, AMPH, methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), .-trifluoromethyl-.-ethyla

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Molecular Mechanisms of Action of 5,6- and 5,7-Dihydroxytryptamine,ferent neuronal types and pathways. Surgical or electrolytic denervation of particular neurotransmitter systems represents methods to accomplish such disruptions. However, in an organ as complex as the brain, these techniques suffer from inherent limitations particularly with respect to selectivity.

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Neurotoxiciy of NMDA Receptor Antagonists, several neuropathological conditions ranging from acute stroke and epilepsy to chronic disorders, e.g., Alzheimer’s disease and Huntington’s chorea (.). These neurotoxic effects of glutamate are thought to be mediated via the activation of .-methyl-D-aspartate (NMDA) subtypes of glutamate receptors

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Toxic Vanilloids,nsumed on a daily basis by one-quarter of the world’s population ., most likely including several readers of this chapter. Other popular vanilloids include piperine, the active ingredient in black pepper, as well as zingerone, responsible for the picancy of ginger (Table 1). Therefore, it is importa