Titlebook: High Throughput Screening; Methods and Protocol William P. Janzen,Paul Bernasconi Book 2009Latest edition Humana Press 2009 Cellular and bi

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Application of Fluorescence Polarization in HTS Assays,r interactions. This chapter reviews the basic theory of fluorescence polarization, the underlying principle for using fluorescence polarization to study interactions between small-molecule fluorophores and macromolecular targets, and representative applications of fluorescence polarization in high-

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Recent Advances in Electrophysiology-Based Screening Technology and the Impact upon Ion Channel Dischannel proteins now implicated across a wide variety of disease states and potential therapeutic applications. Whilst the field now ranks as one of the most dynamic fields for drug discovery research, it has historically been regarded by many researchers as a class of proteins associated with numer

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Automated Patch Clamping Using the QPatch, channels. Despite the high quality of the data generated by this method, in its traditional format, patch clamping has limited use in drug screening due to very low throughput. Over the years, developments in microfabrication have driven the development of planar, multi-aperture technologies that a

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Use of Primary Human Cells in High-Throughput Screens,ting point for a chemistry lead optimisation programme. To enable this it has become commonplace to express the drug target in a recombinant expression system and use this reagent as the source of the biological material to support the HTS campaign. In this chapter we describe an alternative HTS met

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al for achieving optimal benefits from a least squares analysis. This book builds on the fundamentals of statistical methods and provides appropriate concepts that will allow a scientist to use least squares as an effective research tool..Applied Regression Analysis. is aimed at the scientist who wi

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