Titlebook: High Performance Computing; ISC High Performance Amanda Bienz,Michèle Weiland,Carola Kruse Conference proceedings 2023 The Editor(s) (if ap

Systemic

unction of DNA-PK is to promote DNA end synapsis and regulate DNA end processing in the nonhomologous end-joining pathway of double-strand break repair. This regulation is mediated in part by DNA-PK-catalyzed phosphorylation of both itself and the Artemis nuclease, which trims heavily damaged ends t

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Sebastian Oeste,Michael Kluge,Ronny Tschüter,Wolfgang E. Nagelolet light and ionizing radiations or as a consequence of DNA replication or physiological DNA rearrangements. Cells respond to DNA damage by the coordinated induction of cell-cycle arrest and DNA repair or trigger apoptosis if the damage is too extensive. The DNA damage response is induced by two p

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Antony Chazapis,Fotis Nikolaidis,Manolis Marazakis,Angelos Bilashat prevent infinite proliferation: replicative senescence and stress-induced senescence (SIS). In replicative senescence, failure of the DNA polymerase to faithfully duplicate the chromosomal ends leads to progressive telomeric DNA sequence loss with each subsequent cell division and signaling for

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Daniel Medeiros,Gabin Schieffer,Jacob Wahlgren,Ivy Peng It is fundamental to processes as diverse as tissue remodelling during embryogenesis, maintenance of tissue homeostasis in the adult and to both innate and cognate immunity (Ellis et al. 1991; Cohen et al. 1992; Raff 1992; Ameisen et al. 1994; Vaux et al. 1994; Strasser 1995b; Golstein 1997; Jacobs

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Malleable Techniques and?Resource Scheduling to?Improve Energy Efficiency in?Parallel Applicationson represents a significant percentage of the CO2 emissions that occur each year in the world, therefore, it is crucial to develop energy efficiency techniques in order to reduce the energy consumption in HPC systems. In this work, we present a resource scheduler capable of choosing, using real-time

happiness

Towards Achieving Transparent Malleability Thanks to?MPI Process Virtualizationese changes, the process of launching programs has remained largely unchanged, even with the rise of hybridization and accelerators. However, there is a need to express more complex deployments for parallel applications to enable more efficient use of these machines. In this paper, we propose a tran

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A Case Study on?PMIx-Usage for?Dynamic Resource Managementesource management is a very active research field, as it is expected to improve several metrics of resource utilization on HPC systems, such as job throughput and energy efficiency..However, dynamic resource management is complex and requires significant changes to various layers of the software st

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