Titlebook: Hepatitis C: Epidemiology, Prevention and Elimination; Volume 1 Angelos Hatzakis Book 2021 Springer Nature Switzerland AG 2021 pathogenesis

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Laboratory Diagnosis,ection of HCV RNA to confirm an active infection. Assays that detect and quantify HCV core antigen provide an alternative to testing for HCV RNA. Molecular assays to quantify the HCV RNA load, determine the HCV genotype, and detect drug resistance-associated mutations are established in well-resourc

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Natural History of Hepatitis C Infection,tive antiviral treatments allowed observational studies of large untreated cohorts. However, deep understanding of HCV natural history has been always hampered by the asymptomatic course of the disease, both in the acute and in the chronic infection phase. As a consequence, many studies conducted in

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Epidemiology: Modeling of Natural History,hree important ingredients: disease stages, allowed transitions between stages, and corresponding stage-specific transition probabilities. This chapter reviews the approaches that have been used to model the natural history of chronic hepatitis C (CHC). A commonly used approach is to consider diseas

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Eulogy

Hepatitis C Elimination and Advocacy Groups, of hepatitis C on the global public health agenda and resulted in the commitment by 193 countries to eliminate hepatitis C by 2030; and advocacy for viral hepatitis at a global level really began at a meeting of patient representatives from around the world in Barcelona in 2007.

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HCV Elimination in Australia,d 1990s, followed by a decline in early- to mid-2000s, initially related to reduced heroin supply [1]. Ongoing HCV incidence of several 1000 infections/year over the last decade has been despite high-coverage harm-reduction services for people who inject drugs (PWID) [2].

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