Titlebook: Hepatitis C Virus II; Infection and Diseas Tatsuo Miyamura,Stanley M. Lemon,Takaji Wakita Book 2016 Springer Japan 2016 Chronic Hepatitis.H

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Mechanism of Action of Direct-Acting Antivirals: New Insights into the HCV Life Cycleg antivirals (DAA) that target hepatitis C virus (HCV) replication. Combination therapies targeting multiple viral proteins can increase the genetic barrier to resistance, and all-oral, interferon-free regimens combining different classes of DAA are proving highly effective in treating chronic hepat

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Modeling HCV Dynamics in Clinical Practice to Personalize Antiviral Therapynd to study the mode of action of different antiviral therapies. Standard biphasic models well describe the viral load decline in the first 2–4?weeks of therapy, however the hypothesis of a constant clearance rate of the infected cells during longer treatment periods provides unrealistic estimates o